Sermorelin Dosage Guide: How Much to Take
Sermorelin is one of the most popular anti-aging peptides available - but getting the dose right is key. Too low and you won't see results. Here is everything you need to know about Sermorelin dosing.
Dosage at a glance
Why Sermorelin dosage matters
Sermorelin works by stimulating your pituitary gland to release more of its own growth hormone - a process that is highly sensitive to timing and dose. Unlike synthetic HGH, Sermorelin works within your body's natural feedback loop, which means taking it at the right time is just as important as taking the right amount.
Key insight: Sermorelin is most effective when taken 30 minutes before bed. Your body naturally releases most of its growth hormone during the first few hours of deep sleep - Sermorelin amplifies this pulse rather than creating an artificial one.
Sermorelin dosage guide
Standard dose
The most commonly prescribed Sermorelin dose is 200 - 500 mcg per day, injected subcutaneously before bed. Most providers start patients at 200 - 300 mcg and adjust based on response and IGF-1 blood levels after 4 - 6 weeks.
| Goal | Dose | Timing | Frequency |
|---|---|---|---|
| Anti-aging / wellness | 200 - 300 mcg | Before bed | Daily |
| Body composition | 300 - 500 mcg | Before bed | Daily |
| Stacked with Ipamorelin | 100 - 200 mcg each | Before bed | Daily |
| Maintenance | 200 mcg | Before bed | 5 on / 2 off |
Cycle length
Sermorelin is typically used in longer cycles than other peptides because it takes time for the pituitary to respond and for IGF-1 levels to rise. Most people notice improved sleep within 2 - 3 weeks, with more visible changes in energy and body composition appearing after 6 - 8 weeks.
Standard cycles run 3 - 6 months, often followed by a 1 - 2 month break. Many anti-aging protocols use Sermorelin continuously at a lower maintenance dose with periodic blood work to monitor IGF-1 levels.
Note: Sermorelin is a prescription medication in the US. Dosing must be supervised by a licensed provider who can monitor your IGF-1 levels and adjust your protocol accordingly.
Find a Sermorelin clinic near you
The safest way to use Sermorelin is through a licensed clinic with physician oversight. Tides connects you with vetted clinics across the US:
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