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Dosage guide

TB-500 Dosage Guide: Loading, Maintenance & Recovery

TB-500 is one of the most effective healing peptides available - used by athletes and active people to recover from injuries that would otherwise take months. Here is how to dose it correctly.

Updated 2026-7 min read-Educational guide

Dosage at a glance

Loading dose2 - 2.5 mg, twice per week
Maintenance dose2 mg, once per week
AdministrationSubcutaneous injection
Loading phase4 - 6 weeks
Best stackBPC-157 (Wolverine stack)
Inject near injury?Not required - works systemically

TB-500 dosing: loading vs maintenance

TB-500 is typically dosed in two phases - a higher-dose loading phase to kick-start healing, followed by a lower maintenance dose to sustain the benefits. This approach mirrors how the compound works: high initial doses flood the tissue with the healing signals needed for repair, then lower doses keep the process going.

The Wolverine stack: TB-500 is most commonly combined with BPC-157 for dramatically enhanced healing. The two peptides work through complementary mechanisms - TB-500 promotes cell migration and angiogenesis while BPC-157 accelerates tissue repair and reduces inflammation. Together they are significantly more effective than either alone.

TB-500 dosage guide

PhaseDoseFrequencyDuration
Loading - acute injury2 - 2.5 mgTwice per week4 - 6 weeks
Maintenance2 mgOnce per weekOngoing
Prevention / performance2 mgEvery 2 weeksOngoing
Wolverine stack (with BPC-157)2 mg TB-500 + 300 mcg BPC2 - 3x per week4 - 8 weeks

Where to inject TB-500

One of TB-500's key advantages is that it works systemically - you do not need to inject it near the injury site. The peptide distributes throughout your body after injection and reaches damaged tissue regardless of where it is administered. Most people inject subcutaneously in the abdomen for simplicity.

WADA note: TB-500 and its parent compound Thymosin Beta-4 are banned by the World Anti-Doping Agency (WADA). If you compete in tested sports, you should not use TB-500. For recreational athletes and non-competing individuals this is not a concern.

Find a TB-500 clinic near you

The safest way to use TB-500 is through a licensed clinic with physician oversight. Tides connects you with vetted clinics across the US:

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Frequently asked questions

How much TB-500 should I take?
For acute injury recovery, 2 - 2.5 mg twice per week during a 4 - 6 week loading phase is standard. For maintenance or prevention, 2 mg once per week or every two weeks is sufficient. The Wolverine stack combines 2 mg TB-500 with 300 mcg BPC-157 two to three times per week for maximum healing effect.
Do I need to inject TB-500 near the injury?
No. TB-500 works systemically and does not need to be injected at the injury site to be effective. You can inject subcutaneously anywhere on the body - most people use the abdomen. The peptide will distribute through your system and benefit the injured area regardless of injection location.
How long does TB-500 take to work?
Many users report reduced inflammation and improved range of motion within 1 - 2 weeks of starting a loading protocol. More significant structural healing - like tendon or ligament repair - typically becomes noticeable after 3 - 4 weeks. Chronic injuries may take longer to fully respond than acute ones.
How does TB-500 compare to BPC-157?
Both are powerful healing peptides but they work differently. BPC-157 is particularly effective for gut healing and injuries close to joints. TB-500 excels at systemic tissue repair, flexibility improvement, and recovery from larger muscle injuries. They are frequently stacked together because their mechanisms are complementary - this combination is called the Wolverine stack.
Can I use TB-500 for prevention rather than injury?
Yes. Many athletes and active people use TB-500 at low maintenance doses (2 mg every 1 - 2 weeks) as a preventive protocol to support tissue health, reduce injury risk, and speed recovery between training sessions. This is a common use case among serious athletes who cannot afford time off from training.

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This article is for informational and educational purposes only. It does not constitute medical advice. Always consult a licensed healthcare provider before starting any peptide therapy or treatment protocol.